ChAMP: 450k Chip Analysis Methylation Pipeline

نویسندگان

  • Tiffany J. Morris
  • Lee M. Butcher
  • Andrew Feber
  • Andrew E. Teschendorff
  • Ankur R. Chakravarthy
  • Tomasz K. Wojdacz
  • Stephan Beck
چکیده

UNLABELLED The Illumina Infinium HumanMethylation450 BeadChip is a new platform for high-throughput DNA methylation analysis. Several methods for normalization and processing of these data have been published recently. Here we present an integrated analysis pipeline offering a choice of the most popular normalization methods while also introducing new methods for calling differentially methylated regions and detecting copy number aberrations. AVAILABILITY AND IMPLEMENTATION ChAMP is implemented as a Bioconductor package in R. The package and the vignette can be downloaded at bioconductor.org

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عنوان ژورنال:
  • Bioinformatics

دوره 30 3  شماره 

صفحات  -

تاریخ انتشار 2014