Reflux of gastric juice and glue ear in children.
نویسندگان
چکیده
Otitis media with effusion (glue ear) is the most frequent cause of deafness in children. We investigated the role of gastric juice reflux in this disease. We measured pepsin concentrations in middle ear effusions from children using ELISA and enzyme activity assays. 45 (83%) of 54 effusions contained pepsin/pepsinogen at concentrations of up to 1000-fold greater than those in serum. Our data suggest that reflux of gastric juice could be a major cause of glue ear in children.
منابع مشابه
Bronchial asthma and acid reflux into the distal and proximal oesophagus.
The prevalence of pathological gastro-oesophageal reflux in children and adolescents with asthma was studied by 24 hour two level oesophageal pH monitoring in 42 subjects aged 9-20 years with moderate or severe bronchial asthma. The importance of oesophagobronchial nerve reflexes and of aspiration of gastric acid as triggers in asthma was assessed by studying whether episodes of reflux into the...
متن کاملAirway cellularity, lipid laden macrophages and microbiology of gastric juice and airways in children with reflux oesophagitis
BACKGROUND Gastroesophageal reflux disease (GORD) can cause respiratory disease in children from recurrent aspiration of gastric contents. GORD can be defined in several ways and one of the most common method is presence of reflux oesophagitis. In children with GORD and respiratory disease, airway neutrophilia has been described. However, there are no prospective studies that have examined airw...
متن کاملPediatric middle ear infections and gastroesophageal reflux.
OBJECTIVES The pathogenesis of middle ear infections in children is multifactorial and includes infection, anatomical factors, impaired immunologic status, allergy, familial predisposition, male sex, method of feeding and environmental factors. Glue ear remains the commonest cause of deafness in childhood. Gastroesophageal reflux (GOR) is a common problem in the newborn and preschool periods. R...
متن کاملMucosal protective effects of ecabet sodium: pepsin inhibition and interaction with mucus.
Pepsin, acid and Helicobacter pylori are major factors in the pathophysiology of peptic ulcer disease and reflux oesophagitis. Ecabet sodium reduces the survival of H. pylori in the stomach and inhibits pepsin activity in the gastric juice of experimental animals. Here we have investigated the effects of ecabet sodium on some of the factors involved in the dynamics of the mucosal barrier, i.e. ...
متن کاملIn vitro effects of acid and pepsin on mouse middle ear epithelial cell viability and MUC5B gene expression.
OBJECTIVE To examine whether in vitro exposure of mouse middle ear epithelial cells (mMEECs) to conditions that mimic physiologic reflux upregulates Muc5b gene expression and alters cell viability. DESIGN In vitro mMEEC model. SETTING Center for Genetic Medicine Research, Children's National Medical Center, Washington, DC. PARTICIPANTS Cells from the immortalized mMEEC line. MAIN OUTCOM...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Lancet
دوره 359 9305 شماره
صفحات -
تاریخ انتشار 2002