Fetal Exposure to Altered Amniotic Fluid Glucose, Insulin and Insulin- like Growth Factor Binding Protein 1 (IGF BP 1) Occurs Prior to Screening for Gestational Diabetes Mellitus (GDM) Running Title: Amniotic Fluid Glucose and Insulin
نویسندگان
چکیده
Daniel K Tisi, MSc, David H Burns, PhD, 2,4 Gary W Luskey, MD, 3,4 Kristine G Koski, PhD 1,4 1 McGill University, School of Dietetics and Human Nutrition, Montreal, QC, Canada; 2 McGill University, Department of Chemistry, Montreal, QC, Canada; 3 St Mary’s Hospital Centre, Division of Perinatal/Fetal Medicine, Montreal, QC, Canada; and 4 McGill University, Faculty of Medicine, Montreal, QC, Canada.
منابع مشابه
Fetal Exposure to Altered Amniotic Fluid Glucose, Insulin, and Insulin-Like Growth Factor–Binding Protein 1 Occurs Before Screening for Gestational Diabetes Mellitus
OBJECTIVE We explored the possibility that perturbations in amniotic fluid glucose, insulin, and insulin-like growth factor-binding protein 1(IGFBP1) and/or metabolic acids exist before routine screening for GDM. RESEARCH DESIGN AND METHODS We selected consenting mother-infant pairs (n = 408) who met our inclusion criteria (singleton pregnancy, no genetic abnormalities, and no preexisting dia...
متن کاملInsulin-like growth factor II and binding proteins 1 and 3 from second trimester human amniotic fluid are associated with infant birth weight.
The developing fetus begins to swallow amniotic fluid (AF) early in gestation, a process that results in ingestion of numerous growth factors. Our objectives were 2-fold: 1) to assess the concentration and distribution of insulin-like growth factor II (IGF II) and its binding proteins (BP) 1 and 3 in 2nd trimester amniotic fluid using ELISA, and 2) to establish whether concentrations of AF IGF ...
متن کاملAmniotic fluid insulin at 14-20 weeks' gestation: association with later maternal glucose intolerance and birth macrosomia.
OBJECTIVE To examine the hypothesis that early second trimester amniotic fluid (AF) insulin concentration is elevated and later fetal growth is augmented in gravidas demonstrating later oral glucose intolerance. RESEARCH DESIGN AND METHODS In this prospective observational cohort study, AF was sampled at 14-20 weeks' gestation in 247 subjects, and 1-h 50-g oral glucose challenge tests (GCTs) ...
متن کاملFeto-maternal Outcome in Patients with Gestational Diabetes Mellitus in Western India: A Two Years Follow up Study
Objective: Untreated gestational diabetes mellitus (GDM) may lead to increased risk of macrosomia, congenital anomalies, unexplained stillbirth, hypoglycemia and jaundice in newborns. This prospective study was conducted to evaluate feto-maternal outcome in women with GDM. Materials and Methods: Two hundred pregnant women underwent 75grams glucose challenge test according to Diabetes in Pregna...
متن کاملAmniotic fluid insulin and C-peptide as predictive markers for fetal macrosomia, birth injuries, and delivery complications?
BACKGROUND Gestational diabetes mellitus (GDM) occurs in 3-5% of all pregnancies. GDM increases both maternal and fetal risks, causes fetal macrosomia, and hence increases the rates of caesarean sections and delivery complications such as shoulder dystocia. An early predictive marker and consequent early treatment could be beneficial, so amniotic fluid insulin and C-peptide have been examined i...
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تاریخ انتشار 2010