Synthesis and Pharmacological Activity of Fluorinated Tryptamine Derivatives.
نویسندگان
چکیده
fall in stimulant activity. \T7hile SI1 inliihits t l i c stiinulaiit response to serotonin 011 tlic iso1:tted rat fundus strip, the 2-aminopropyl cwiipountl SI I 1 produced powerful contractions of t,lic same tissue. ‘l’lic piwetice of a 5-amino group arid the sidc cliairi i l l the %-position characterize the compounds of (Group I ) L\ Iiicli diow very w a k antagonism towards serotonin, liibtamine, and acetylcholiiic. \Tit11 tltc exccpt i o i t of compound XIT, serotonin-iiiducctl vasoconsti ictioiiwa3 not aiitagonized but therewas partial iiiliihitioii of epiiicplirinc and iiorepiiiephriiie \mm!onstriction o i i tlic isolated perfused rat hindquarters. r17 ic compounds of Group -1 exhibit the variability aitd iiotiselcctivity in pharmacological properties churnctcristic of thc corresponding itidole derivatives.21f ? ?
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عنوان ژورنال:
- Journal of medicinal chemistry
دوره 6 شماره
صفحات -
تاریخ انتشار 1963