Novel Challenges in Crystal Engineering: Polymorphs and New Crystal Forms of Active Pharmaceutical Ingredients
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منابع مشابه
Crystal engineering of active pharmaceutical ingredients to improve solubility and dissolution rates.
The increasing prevalence of poorly soluble drugs in development provides notable risk of new products demonstrating low and erratic bioavailability with consequences for safety and efficacy, particularly for drugs delivered by the oral route of administration. Although numerous strategies exist for enhancing the bioavailability of drugs with low aqueous solubility, the success of these approac...
متن کاملCrystal Engineering Studies: polymorphs and co-crystals
We review the key topics of one of the areas with the biggest impact of the last years in the chemical and pharmaceutical industry that is Crystal Engineering. The relevance of polymorphs and co-crystals from different points of view is been highlighted and broadly illustrated by means of several recent examples of studies carried out in this field. In addition, the most suitable instrumental t...
متن کاملCharge density and optical properties of multicomponent crystals containing active pharmaceutical ingredients or their analogues.
Active pharmaceutical ingredients (APIs), through their favourable donor/acceptor spatial distribution and synthon formation flexibility, are attractive building blocks in modern materials crystallography. The optical properties of a crystal strongly depend on two factors, i.e. the spatial distribution of molecules in the crystal structure and the electronic properties of molecular building blo...
متن کاملCrystal engineering of pharmaceutical co-crystals from polymorphic active pharmaceutical ingredients.
The carboxylic acid-primary amide supramolecular heterosynthon is exploited for the generation of pharmaceutical co-crystals that contain two active pharmaceutical ingredients that are polymorphic in their pure forms.
متن کاملpolymorphs, solvates and co-crystals. Functional groups that are self-complementary are capable of forming either a supramolecular homosynthons (eg-acid-acid and amide-amide homodimers or a supramolecular heterosynthon (carboxylicacid-amide heterodimers)
The emerging role of supramolecular chemistry and crystal engineering in pharmaceutical science has been influenced significantly by the interest in pharmaceutical cocrystals. Pharmaceutical co-crystals are co-crystals that are formed between an API (active pharmaceutical ingredient) and a co-crystal former that is a solid under ambient conditions. APIs contain functional groups that engage in ...
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تاریخ انتشار 2017