Neurodegeneration: A Non-Apoptotic Role for AIF in the Brain
نویسنده
چکیده
A recent report provides new insights into the mechanisms of neurodegeneration. In a mouse mutant with progressive cerebellar and retinal degeneration, the expression of the apoptotic protein AIF was found to be downregulated leading paradoxically to apoptosis of neurons that is associated with an imbalance in free radical metabolism and cell cycle re-entry.
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عنوان ژورنال:
- Current Biology
دوره 13 شماره
صفحات -
تاریخ انتشار 2003