The Report in the Current Issue of Sleep by Fujiki Et Al. Reinforces Prior Work That Suggests That Hypocretin (hcrt, Also Known as Orexin) Adminis- Tration Will Be an Effective Treatment for Human

AL. REINFORCES PRIOR WORK THAT SUGGESTS THAT HYPOCRETIN (HCRT, ALSO KNOWN AS OREXIN) ADMINISTRATION WILL BE AN EFFECTIVE TREATMENT FOR HUMAN NARCOLEPSY. Most human narcolepsy is caused by a loss of hypocretin neurons.1-3 That finding suggested that Hcrt administration might be an effective treatment for narcolepsy. Work in our laboratory showed that intravenous (IV) Hcrt administration reduced symptoms of canine genetic narcolepsy.4 Although the Fujiki et al. paper emphasizes technical problems associated with studying these effects, it confirms key aspects of these hopeful findings.