Analysis of Extractable and Leachable (E&L) Compounds Using a Low-Energy EI-Capable High-Resolution Accurate Mass GC/Q-TOF

Accurate compound identification is critical to the study of extractables and leachables (E&L) [1]. The complexity of E&L extracts, containing chemicals with a wide range of classes and concentrations, poses challenges for compound identification [2]. The GC-amenable portion of E&L studies is conventionally carried out with a unit mass GC/MS in standard EI full scan mode, with compound identification through NIST GC/MS library searching. Limited knowledge can be obtained from this technique for those compounds detected without a convincing library match score.