Absolute cerebral blood volume (CBV) quantification without contrast agents using inflow vascular-space-occupancy (iVASO) with dynamic subtraction
نویسندگان
چکیده
M. J. Donahue, B. J. MacIntosh, E. Sideso, M. Bright, J. Kennedy, A. Handa, and P. Jezzard Clinical Neurology, The University of Oxford, Oxford, United Kingdom, Nuffield Department of Clinical Medicine, The University of Oxford, Oxford, United Kingdom, Advanced MRI Section, LFMI, NINDS, The National Institutes of Health, Bethesda, MD, United States, Nuffield Department of Surgery, The University of Oxford, Oxford, United Kingdom
منابع مشابه
Arterial cerebral blood volume (aCBV)-weighted inflow vascular-space-occupancy (iVASO) provides complementary hemodynamic information to dynamic susceptibility contrast in patients with stenotic artery disease
Introduction. Active and passive mechanisms for controlling cerebral blood volume (CBV) at the arterial, capillary and venous levels are incompletely understood, yet central to cerebral blood flow (CBF) regulation. Furthermore, knowledge of CBV changes in different vascular compartments would be important for investigations of fMRI contrast and in clinical scenarios where flow-volume coupling m...
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Introduction: Arteriolar cerebral blood volume (CBVa) is an important physiological parameter regulating tissue perfusion. We demonstrate a novel approach to measure absolute CBVa (CBVa) based on a variant of vascular-space-occupancy (VASO) MRI (1). VASO is a contrast-agent-free MRI technique that is sensitized to micro-vascular CBV changes through nulling of blood signal. Instead of the spatia...
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Introduction. Active cerebral blood volume (CBV) changes, facilitated by relaxation of smooth muscle surrounding arterioles, are closely related to cerebral blood flow (CBF) regulation and are incompletely understood in many cerebrovascular disorders. Furthermore, knowledge of arterial CBV (aCBV) in traditional cerebrovascular response (CVR) studies may help disentangle the many factors that op...
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Introduction: Arterial and post-arterial cerebral blood volumes (CBV) have different physiological and functional roles in the brain. Arterial vessels are the major active regulator of cerebral blood flow (CBF), while post-arterial (capillary, venous) vessels mostly dilate passively to accommodate changes in CBF. A change in CBV is one of the primary factors affecting the stimulus evoked BOLD s...
متن کاملCorrection for the T2 effect of contrast agent on absolute CBV quantification using VASO
Introduction Absolute cerebral blood volume (aCBV) can be assessed by utilizing the signal difference of vascular space occupancy (VASO) sequence before and after injection of T1 shortening contrast agent.[1] In previous report, the T2 effect of contrast agent is proved to influence the accuracy of absolute CBV quantification using VASO.[2] Other than using extrapolation by a multi-echo sequenc...
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تاریخ انتشار 2008