In vitro vinblastine-induced tubulin paracrystals.
نویسندگان
چکیده
Purified calf brain tubulin has been induced to self-aggregate in vitro into paracrystalline structures by the anti-cancer drug vinblastine. The size, shape, optical birefringence, and drug stoichiometry of these tubulin-vinblastine paracrystals are similar to those of paracrystals formed in vivo. Similar structures can be formed with vincristine and desacetylvinblastine, but not with colchicine or podophyllotoxin.
منابع مشابه
The effects of mitotic inhibitors on the structure of vinblastine-induced tubulin paracrystals from sea-urchin eggs.
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عنوان ژورنال:
- The Journal of biological chemistry
دوره 257 17 شماره
صفحات -
تاریخ انتشار 1982