Parallel microflow photochemistry: process optimization, scale-up, and library synthesis.
نویسندگان
چکیده
A novel, multimicrocapillary flow reactor (MμCFR) was constructed and applied to a series of sensitized photoadditions involving 2(5H)-furanones. The reactor allowed for rapid and energy-, time-, and space-efficient sensitizer screening, process optimization, validation, scale-up, and library synthesis.
منابع مشابه
Recent advances in microflow photochemistry.
This review summarizes recent advances in microflow photochemical technologies and transformations. The portfolio of reactions comprises homogeneous and heterogeneous types, among them photoadditions, photorearrangements, photoreductions, photodecarboxylations, photooxygenations and photochlorinations. While microflow photochemistry is most commonly employed as a micro-scale synthesis tool, sca...
متن کاملMicroflow High-p,T Intensification of Vitamin D3 Synthesis Using an Ultraviolet Lamp
Herewith a new process concept for synthesis is presented which combines both UV-photoirradiation and high-p,T intensification (photo-high-p,T) in continuous flow. The application of this procedure to Vitamin D3 synthesis promotes thermal shifting of the equilibrium from the reaction intermediate to the product. This is enabled by microreactors which allow operation under harsh conditions such ...
متن کاملA combined continuous microflow photochemistry and asymmetric organocatalysis approach for the enantioselective synthesis of tetrahydroquinolines
A continuous-flow asymmetric organocatalytic photocyclization-transfer hydrogenation cascade reaction has been developed. The new protocol allows the synthesis of tetrahydroquinolines from readily available 2-aminochalcones using a combination of photochemistry and asymmetric Brønsted acid catalysis. The photocylization and subsequent reduction was performed with catalytic amount of chiral BINO...
متن کاملSpecial Issue: Design and Engineering of Microreactor and Smart-Scaled Flow Processes
Reaction-oriented research in flow chemistry and microreactor has been extensively focused upon in special journal issues and books. On a process level, this resembled the " drop-in " (retrofit) concept with the microreactor replacing a conventional (batch) reactor. Meanwhile, with the introduction of the mobile, compact, modular container technology, the focus is more on the process side, incl...
متن کاملAmmonium salts as economical and eco-friendly N-sources applied to green, simple and scale-up synthesis of trialkyl amines in water
We have introduced a selective synthesis of tertiary amines using alkyl halide and ammonium salts as the amine sources in water. This green process has outstanding superiorities, such as being eco-friendly, possessing ammonium salts, and using water as a green solvent in the absence of organic ligands or catalysts. It is worth mentioning that the presence of t-Butyl alcohol and potassi...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Organic letters
دوره 14 17 شماره
صفحات -
تاریخ انتشار 2012