Selection bias in the assessment of gene-environment interaction in case-control studies.
نویسندگان
چکیده
Selection bias is a common concern in epidemiologic studies, particularly case-control studies. Selection bias in the odds ratio occurs when participation depends jointly on exposure and disease status. General results for understanding when selection bias may affect studies involving gene-environment interactions have not yet been developed. In this paper, the authors show that the assessment of gene-environment interactions will not be subject to selection bias under the assumption that genotype does not influence participation conditional on exposure and disease status. This is true even when selection, including self-selection of subjects, is jointly influenced by exposure and disease and regardless of whether the genotype is related to exposure, disease, or both. The authors present an example to illustrate this concept.
منابع مشابه
تحلیل برآورد اثر متقابل ژن ـ محیط در بیماران مبتلا به سرطان پستان
Background and objectives: There is growing interest in assessing gene-environment interaction in the course of case-control studies. Difficulties related to the sampling of controls have led to the development of a range of non-traditional methods that do not require controls for estimating gene-environment interaction. One of these new modalities is the case-only approach, in which the asse...
متن کاملطراحیهای تنها موردی و مورد- شاهدی در ارزیابی اثر متقابل ژن- محیط با استفاده از دادههای سرطان پستان
Background and Objectives: The role of gene-environment interaction in epidemiology has been widely considered. The traditional methods of studying the gene-environment interaction need appropriate control groups which their selection may be associated with some problems. Therefore, new methods have been created to study these interactions from which are the case-only designs. In this method,...
متن کاملA Comparison of Case-Control and Case-Only Designs to Investigate Gene-Environment Interactions Using Breast Cancer Data
Background: The traditional methods of studying the gene-environment interactions need a control group. However, the selection of an appropriate control group has been associated with problems. Therefore, new methods, such as case-only design, have been created to study such interactions. The objective of this study was to compare the case-only and case-control designs using data from patients ...
متن کاملبرآورد اثر متقابل ژن - محیط در سرطان پستان با مطالعات مورد - شاهد و فقط مورد
Background and Aim: Limitations of the traditional methods for assessing G*E interaction- including case-control studies- led to development of several non-traditional approaches. This study aims to assess the interaction between the genetic background (history of breast cancer in first degree relatives) and environmental influences (reproductive/menstrual factors) in patients with breast cance...
متن کاملMisclassification in case-control studies of gene-environment interactions: assessment of bias and sample size.
In studies of gene-environment interactions, exposure misclassification can lead to bias in the estimation of an interaction effect and increased sample size. The magnitude of the bias and the consequent increase in sample size for fixed misclassification probabilities are highly dependent on the prevalence of the misclassified factor and on the interaction model. This paper describes a relativ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- American journal of epidemiology
دوره 158 3 شماره
صفحات -
تاریخ انتشار 2003