Adrenocortical steroid response to ACTH in different phenotypes of non-obese polycystic ovary syndrome
نویسندگان
چکیده
UNLABELLED BACKGROUND Adrenal androgen excess is frequently observed in PCOS. The aim of the study was to determine whether adrenal gland function varies among PCOS phenotypes, women with hyperandrogenism (H) only and healthy women. METHODS The study included 119 non-obese patients with PCOS (age: 22.2 ± 4.1y, BMI:22.5 ± 3.1 kg/m2), 24 women with H only and 39 age and BMI- matched controls. Among women with PCOS, 50 had H, oligo-anovulation (O), and polycystic ovaries (P) (PHO), 32 had O and H (OH), 23 had P and H (PH), and 14 had P and O (PO). Total testosterone (T), SHBG and DHEAS levels at basal and serum 17-hydroxprogesterone (17-OHP), androstenedione (A4), DHEA and cortisol levels after ACTH stimulation were measured. RESULTS T, FAI and DHEAS, and basal and AUC values for 17-OHP and A4 were significantly and similarly higher in PCOS and H groups than controls (p < 0.05 for all) whereas three groups did not differ for basal or AUC values of DHEA and cortisol. Three hyperandrogenic subphenotypes (PHO, OH, and PH) compared to non-hyperandrogenic subphenotype (PO) had significantly and similarly higher T, FAI, DHEAS and AUC values for 17-OHP, A4 and DHEA (p < 0.05). All subphenotypes had similar basal and AUC values for cortisol. CONCLUSION PCOS patients and women with H only have similar and higher basal and stimulated adrenal androgen levels than controls. All three hyperandrogenic subphenotypes of PCOS exhibit similar and higher basal and stimulated adrenal androgen secretion patterns compared to non-hyperandrogenic subphenotype.
منابع مشابه
Glucose action and adrenocortical biosynthesis in women with polycystic ovary syndrome.
OBJECTIVE To determine if insulin or glucose action plays a role in adrenocortical steroidogenesis in the polycystic ovary syndrome (PCOS). DESIGN Prospective cohort study. SETTING Academic medical center. PATIENT(S) Nine reproductive-aged patients with PCOS and nine age-, race-, and body mass index-matched controls. MAIN OUTCOME MEASURE(S) Insulin-modified frequently sampled intravenou...
متن کاملP-182: The Comparison of Clinical and Laboratory Characteristics in Obese and Normal Weight Women with Polycystic Ovary Syndrome
Background: The main characteristic of polycystic ovary syndrome (PCOS) is oligomenorrhea with clinical and biochemical signs of hyperandrogenism(HA) and the phenotypic spectrum of PCOS is very broad. There are very limited studies about the features of patients with PCOS in Iran. The purpose of this study is to compare the clinical and laboratory characteristics of PCOS between the overweight ...
متن کاملP-38: Comparison of Oxidative Stress and Antioxidative Status in non Obese Women with and without Polycystic Ovary Syndrome
متن کامل
P-216: Common Polymorphisms of StAR Gene Are Not Associated with Polycystic Ovary Syndrome in Iranian Patients
Background: Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders, affecting 5-10% of reproductive aged women. High levels of androgen hormone can be accounted as the most important symptoms in PCOS. Androgen is the precursor of steroid biosynthesis in ovary. The transport of cholesterol to the inner mitochondrial membrane through StAR protein is also necessary for andr...
متن کاملبررسی عوامل خطرزای بیماری‌های قلبی و عروقی بر حسب فنوتیپ‌های سندرم تخمدان پلی‌کیستیک در دختران 18-14 ساله دبیرستانی شهر شیراز 1389
Introduction: In patients with polycystic ovary syndrome hyperinsulinaemia, insulin resistance, dyslipidemia and hyperglycemia may represent an increased risk for coronary cardiovascular disease .This study aimed to investigate risk factors for cardiovascular disease based on polycystic ovary syndrome phenotypes in Shiraz. Methods: This Cross-sectional study was performed on 3200 students aged...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره 5 شماره
صفحات -
تاریخ انتشار 2012