Antibacterial Activity of Silver Nanoparticles (AgNPs) in Staphylococcus aureus and Cytotoxicity Effect in Mammalian Cells

Staphylococcus aureus is a type of Gram-positive bacteria that can cause different healthcare-associated infections. Silver nanoparticles (AgNPs) are considered to be used in various applications against bacteria that are resistant to common antibiotics or even multiresistant bacteria as the S. aureus. This work evaluated the antimicrobial activity of AgNPs in strains of S. aureus resistant to a large number of antibiotics. Regarding antimicrobial susceptibility tests, the reference strain showed sensitivity for almost 75% of the evaluated antibiotics and also to AgNPs suspension. The clinical strains showed resistance to 80% of antibiotics tested but one of the clinical strains was more sensitive to AgNPs suspension. Silver nanoparticles were non-cytotoxicity at 0.156μg/ mL concentration in normal mouse fibroblasts 929 and tumoral HeLa and HepG2 cells.