Prevention of experimental subarachnoid hemorrhage-induced intracranial arterial vasonecrosis with phosphodiesterase inhibitor phthalazinol (EG-626).
نویسندگان
چکیده
Experiments in monkeys have demonstrated that the chronic vasospasm and arterial injury reaction produced by subarachnoid blood injection can be prevented by treatment with the phosphodiesterase inhibitor phthalazinol. This protective effect, which is present even when the drug treatment is initiated after the subarachnoid blood injection, is presumed to occur because of the platelet inhibiting effect of phthalazinol.
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1. Wilkins RH: Attempts at treatment of intracranial arterial spasm in animals and human beings. Surg Neurol 1: 148-159, 1973 2. Alksne JF: Myonecrosis in chronic experimental vasospasm. Surg 76: 1-7, 1974 3. Alksne JF, Greenhoot JH: Experimental catecholamine-induced chronic cerebral vasospasm: Myonecrosis in vessel wall. J Neurosurg 41: 440-445, 1974 4. Alksne JF, Branson PJ: A comparison of ...
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عنوان ژورنال:
- Stroke
دوره 10 6 شماره
صفحات -
تاریخ انتشار 1979