J . Virol . Jeang Rene F . Chun , O . J . Semmes , Christine Neuveut and Kuan - Teh Immunodeficiency Virus Type 1 Tat Modulation of Sp
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Cell cycle dysregulation by HTLV-I: role of the tax oncoprotein.
HTLV-I is a human retrovirus which is the etiological agent for adult T-cell leukemia. The virus encodes a 40 kDa oncoprotein, Tax, which has no cellular counterpart. Findings from several laboratories over the past decade have shown that over-expression of the Tax oncoprotein is wholly sufficient to transform animal cells. Emerging evidence supports that Tax transforms cells through dysregulat...
متن کاملHIV-1 Tat: Structure and Function
Most viruses encode functions for regulating genome transcription. Examples include the SV40 T-antigen, the adenovirus E1a protein, and the herpes virus immediate-early proteins. For the human immunodeficiency viruses (HIV), Tat functions similarly, though not identically, to those other activators. Over the past decade, we have learned much about Tat, both in structure and in function. The int...
متن کاملHuman immunodeficiency virus type 1 tat protein activates transcription factor NF-kappaB through the cellular interferon-inducible, double-stranded RNA-dependent protein kinase, PKR.
The transactivator protein of human immunodeficiency virus type 1 (HIV-1) (Tat) is a powerful activator of nuclear factor-kappaB (NF-kappaB), acting through degradation of the inhibitor IkappaB-alpha (F. Demarchi, F. d'Adda di Fagagna, A. Falaschi, and M. Giacca, J. Virol. 70:4427-4437, 1996). Here, we show that this activity of Tat requires the function of the cellular interferon-inducible pro...
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Twenty-five years after the discovery and isolation of the human immunodeficiency virus by French and American scientists, much progress has been made in basic research, clinical treatment, and public health prevention measures for acquired immunodeficiency syndrome. Here, we summarize, in brief, advances that have been achieved and provide some perspectives on future challenges.
متن کاملHuman immunodeficiency virus type 1 Vpr interacts with antiapoptotic mitochondrial protein HAX-1.
Human immunodeficiency virus type 1 viral protein R (Vpr) is required for viral pathogenesis and has been implicated in T-cell apoptosis through its activation of caspase 3 and caspase 9 and perturbation of mitochondrial membrane potential. To understand better Vpr-mitochondria interaction, we report here the identification of antiapoptotic mitochondrial protein HAX-1 as a novel Vpr target. We ...
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تاریخ انتشار 1998