Analysis of ancient human genomes

Extraction and Analysis of Ancient DNA from Human Remains of Masjede Kabood Burial Site

Using Ancient Samples in Projection Analysis

Projection analysis is a tool that extracts information from the joint allele frequency spectrum to better understand the relationship between two populations. In projection analysis, a test genome is compared to a set of genomes from a reference population. The projection's shape depends on the historical relationship of the test genome's population to the reference population. Here, we explor...

The Genomic Health of Ancient Hominins.

The genomes of ancient humans, Neandertals, and Denisovans contain many alleles that influence disease risks. Using genotypes at 3,180 disease-associated loci, we estimated the disease burden of 147 ancient genomes. After correcting for missing data, genetic risk scores (GRS) were generated for nine disease categories and the set of all combined diseases. We used these genetic risk scores to ex...

Comparative scaffolding and gap filling of ancient bacterial genomes applied to two ancient Yersinia pestis genomes

Yersinia pestis is the causative agent of the bubonic plague, a disease responsible for several dramatic historical pandemics. Progress in ancient DNA (aDNA) sequencing rendered possible the sequencing of whole genomes of important human pathogens, including the ancient Y. pestis strains responsible for outbreaks of the bubonic plague in London in the 14th century and in Marseille in the 18th c...

Psychological Analysis of Kiumarth Myth in the Light of the Personality Psychology of Jung

Mythology allocated a large part, fundamental and effectively to the human mind. The knowledge of mythology in fact recognizes the important infrastructure of ideas, culture and civilization. One of the most common ways to study mythology is to implement psychological ideas in mythology. The result is not only a better understanding of mythology, but also a better understanding of human psyche ...

Scaffolding of Ancient Contigs and Ancestral Reconstruction in a Phylogenetic Framework

Ancestral genome reconstruction is an important step in analyzing the evolution of genomes. Recent progress in sequencing ancient DNA led to the publication of so-called paleogenomes and allows the integration of this sequencing data in genome evolution analysis. However, the assembly of ancient genomes is fragmented because of DNA degradation over time. Integrated phylogenetic assembly address...