Neutron crystallographic evidence of lipase–colipase complex activation by a micelle dimensional structure of the uncomplexed human enzyme

Institut de Biologie Structurale Jean-Pierre Ebel, CEA-CNRS, of PL in solution. The PL–CL structure (van Tilbeurgh 41 Avenue des Martyrs, 38027 Grenoble Cedex 1, 2Large Scale et al., 1993), in turn, shows that the active site is exposed Structures Group, Institut Laue-Langevin, BP 156, 38042 Grenoble and the flap makes a series of polar contacts with CL. and 3Laboratoire de Bioénergétique et d’Ingénierie des Protéines, Together, these structures have provided a comprehensive UPR 9036 CNRS, BP 71, 13402 Marseille Cedex 9, France