Association of habitual dietary resveratrol exposure with the development of frailty in older age: the InCHIANTI Study

1 From the Biomarkers and Nutrimetabolomics Laboratory, Nutrition and Food Science Department, XaRTA, INSA, Campus Torribera, Pharmacy Faculty, University of Barcelona, Spain (MR, CA-L, MU-S); Biomarkers group (BMA), Nutrition and Metabolism Section (NME), International Agency for Research on Cancer (IARC), Lyon, France (RZ-R); Geriatric Rehabilitation Unit, Azienda Sanitaria Firenze, Florence, Italy (SB); Clinical Research Branch, National Institute on Aging, NIH, Baltimore, Maryland, United States (LF); Geriatrics and Geriatric Emergency Care, Italian National Research Centre on Aging (INRCA), Ancona, Italy (AC). 2 Supported by the JPI HDHL FOODBALL Project (PCIN-2014-133-MINECO-Spain). Partially funded by: the International Nut and Dried Fruit Council Foundation (INC) in collaboration with the Bosch i Gimpera Foundation (FBG307906), and the award of 2014SGR1566 from the Generalitat de Catalunya‟s Agency AGAUR. This research was also supported by: PI13/01172 Project (Plan N de I+D+i 2013-2016) cofounded by ISCII-Subdirección General de Evaluación y Fomento de la Investigación, and Fondo Europeo de Desarrollo Regional (FEDER), COST Action POSITIVE FA1403, and the University of Barcelona, Barcelona Knowledge Campus (BKC), Campus of International Excellence (CEI) programme of the Spanish Ministry of Education, Culture and Sport. The InCHIANTI study is supported in part by the Italian Ministry of Health and by the United States National Institute on Aging (NIA). M.U.-S. would like to thank the “Ramón y Cajal” program (RYC-2011-09677) from MINECO and the Fondo Social Europeo. 3 Reprints not available. Address correspondence to C Andres-Lacueva, Biomarkers and Nutrimetabolomic Laboratory, Nutrition and Food Science Department, Campus Torribera, Pharmacy Faculty, University of Barcelona, Av. Joan XXIII s/n, 08028 Barcelona, Spain. E-mail: [email protected]. Phone: +34.934034840. 4 Abbreviations used: ADL, Activities of Daily Living; BMI, body mass index; CES-D, Center for Epidemiologic Studies Depression scale; EPIC, European prospective study into cancer and nutrition study; FFQ, food frequency questionnaire; FS, frailty syndrome; hsCRP, high-sensitivity C-reactive protein; IADL, Instrumental Activities of Daily Living; IL-1ra, Interleukin-1 receptor antagonist; IL-6, Interleukin-6; InCHIANTI, Invecchiare in Chianti; LC-MS/MS, liquid chromatography-tandem mass spectrometry; MMSE, Mini-Mental State Examination; SPE, solid-phase extraction; TDR, total dietary resveratrol; TNF-α, Tumor necrosis factor-α; TUR, total urinary resveratrol; SIRT1, sirtuin 1. List of author names (for PubMed indexing): Rabassa M, Zamora-Ros R, Urpi-Sarda M, Bandinelli S, Ferrucci L, Andres-Lacueva C, Cherubini A.