Morphology of Vocal Fold Mucosa: Histology to Genomics
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چکیده
Voice is created as a consequence of vocal fold vibration. The quality of voice production is dependent upon the uniquely layered ultrastructure of the vocal folds, which is defined by its cellular and extracellular matrices (ECMs). Pathological changes of the vocal fold ECM alter vocal quality secondary to loss of normal vibratory function and alteration of tissue viscosity and thereby create mild to debilitating levels of dysphonia. Select characteristics of the layered structure have been documented for normal and pathological states, but methodologies have been limited to histological and immunohistological analyses. Little has been completed using cellular, molecular, or genetic techniques such as gene expression analysis (i.e., polymerase chain reaction or northern analysis) and protein synthesis analysis (i.e., Western blot or enzyme-linked immunosorbent assay [ELISA]). Significant unanswered questions concerning the ECM and its effect on vocal fold vibration remain. However, recent advances in protein and genetic engineering have allowed for expansion of our knowledge of the ECM, particularly regarding its role in providing homeostasis between the cellular elements and the surrounding stromal matrix. This chapter begins with an introduction to ECM biology, followed by a section on characteristics of the ECM specific to the vocal fold lamina propria. The final section contains descriptions of benign vocal fold lesions detailed by characteristics of their ECM.
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Vocal fold superficial layer of lamina propria histology after the position of mucosa pediculated flap : canine experimental study Summary
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[Vocal fold superficial layer of lamina propria histology after the position of mucosa pediculated flap: canine experimental study].
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تاریخ انتشار 2010