Simvastatin targets the IL-6 signalling cascade in human melanoma cells
نویسندگان
چکیده
Background In the last years the number of melanoma patients has increased markedly. High plasma levels of interleukin-6 (IL-6) are associated with bad prognosis and reduction in overall survival of these patients. Statins, HMG-CoA reductase inhibitors, are well-tolerated therapeutics for hypercholesterolemia. We have recently shown that simvastatin triggers apoptosis in 518A2 human melanoma cells which is paralleled by concentration-dependent changes in autocrine IL-6 secretion. Here, we investigated the impact of simvastatin on the IL-6 pathway.
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عنوان ژورنال:
دوره 11 شماره
صفحات -
تاریخ انتشار 2011