Cervical spinal cord compression complicating the clinical course of Charcot-Marie-Tooth type 1.

To cite: Evans MRB, Laurá M, Chandrashekar H, et al. BMJ Case Rep Published online: [please include Day Month Year] doi:10.1136/bcr-2015213486 DESCRIPTION A 73-year-old woman with Charcot-Marie-Tooth type 1 (CMT1) had followed a typical slowly progressive course since onset. She had bilateral distal upper and lower limb weakness and walked with a single stick from 50 years of age, requiring two sticks following a left internal capsular stroke at 63 years of age. Neurological examination was consistent with a severe, length-dependent sensorimotor neuropathy: distal wasting/weakness in all limbs, with additional mild right lower limb pyramidal pattern weakness consistent with the previous stroke. There was decreased vibration sense and proprioception to the knees, with loss of pin sensation to knees and elbows. Reflexes were absent. Plantar responses were flexor. Neurophysiology revealed homogenous slowing of motor nerve conduction velocities (24 m/s in right median nerve), with absence of temporal dispersion, conduction block, and of accentuated proximal and distal slowing, consistent with an inherited demyelinating neuropathy. Following years of slow progression, at 73 years of age she was admitted following three