Polyglutamine Disease: Acetyltransferases Awry

نویسنده

  • Robert E. Hughes
چکیده

Recent evidence indicates that inhibition of histone acetyltransferases may be a primary cause of cellular pathogenesis in polyglutamine diseases such as Huntington disease; the results raise the possibility that pharmacologic manipulation of protein acetylation levels could be of therapeutic benefit.

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عنوان ژورنال:
  • Current Biology

دوره 12  شماره 

صفحات  -

تاریخ انتشار 2002