An immunohistochemical analysis of naturally occurring chancroid.
نویسندگان
چکیده
Haemophilus ducreyi is a major cause of genital ulcer disease in many developing countries and is associated with augmented transmission of human immunodeficiency virus (HIV). However, the mechanisms through which H. ducreyi produces ulceration are poorly understood. The characteristics of the host response to H. ducreyi and the pathobiology of its potential contribution to increased HIV susceptibility are not known. Chancroid ulcer biopsies from 8 patients were analyzed histologically and immunohistochemically. All biopsies had perivascular and interstitial mononuclear cell infiltrates that extended deep into the dermis. The infiltrate, which contained macrophages and CD4 and CD8 lymphocytes, was consistent with a delayed hypersensitivity type cell-mediated immune response. The recruitment of CD4 T lymphocytes and macrophages may in part explain the facilitation of HIV transmission in patients with chancroid.
منابع مشابه
Bacterial Expression and Functional Characterization of A Naturally Occurring Exon6-less Preprochymosin cDNA
Chymosin (Rennin EC 3.4.23.4), an aspartyl proteinase, is the major proteolytic enzyme in the fourthstomach of the unweaned calf, and it is formed by proteolytic activation of its zymogene, prochymosin.Following the cloning of synthesized cDNAs on mRNA pools extracted from the mucosa of the calf fourthstomach, we have identified an alternatively spliced form of preprochymosin ...
متن کاملTHE ROLE OF TREATMENT ON CONTROLLING CHANCROID PREVALENCE
Chancroid is a highly infectious and curable sexually transmitted disease caused by the bacterium Haemophilus Ducreyl (also known as H. Ducreyl). A deterministic mathematical model for investigating the role of treatment on controlling chancroid epidemic is formulated and rigorously analyzed. A threshold quantity known as the productive number, which measures the number of secondary infections ...
متن کاملAn evaluation of some oxidative and enzymatic biomarkers in different stages of naturally occurring copper poisoning in sheep
BACKGROUND: The early stage of Copper poisoning is difficult to be clinically diagnosed in sheep and has not been documented clearly yet. OBJECTIVES: To assess biomarkers in predicting early Copper poisoning in sheep, blood samples were collected from several groups of animals from a naturally Copper poisoning occurrence in an industrial region. METHODS: Animals were divided into four experimen...
متن کاملClinical and in situ cellular responses to Haemophilus ducreyi in the presence or absence of HIV infection.
We aimed to determine if the clinical and histological features of chancroid are altered by HIV infection. Male patients presenting to the Nairobi special treatment clinic with a clinical diagnosis of chancroid were eligible for the study. A detailed history, physical examination, swabs for Haemophilus ducreyi culture and blood for HIV serology, syphilis serology and CD4 counts were obtained fr...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- The Journal of infectious diseases
دوره 174 2 شماره
صفحات -
تاریخ انتشار 1996