Shift of Equiluminance in Congenital Color Vision Deficiencies: Pattern-ERG, VEP and Psychophysical Findings

We compared electrophysiological responses [pattern-ERG (PERG) and VEP] and psychophysical measures to color stimuli to separate different forms of anomalous color vision. PERG and VEP were recorded from seven normals and 14 subjects with congenital color vision deficiencies. Stimuli were color checkerboards with 0.5 deg check size, phase reversing at 34 rev/sec. The luminances of the red and green parts were varied in opposite direction from 0 to 30 cd/m2, while the hue of individual squares and space-averaged luminance were held constant. This allowed for one equiluminance condition where flicker appeared fused. In the seven normals, the subjective equiluminance was reached at a luminance ratio red/(red + green) = 0.50-0.53. At that point, the PERG amplitude was moderately, and the VEP amplitude sharply reduced. In 14 color anomalous subjects both the PERG and VEP were sharply reduced at equiluminance. These dips were shifted compared to normals and the dip position corresponded to the predicted luminance ratios obtained by calculations from L- and M-cone activation using the Smith-Pokorny transformation. As we found a close correlation of the VEP-dip position and the anomalous quotient, these electrophysiological measures may allow objective assessment of color vision deficiencies.