Optical Tweezers: Measuring Piconewton Forces

نویسنده

  • Mark C. Williams
چکیده

Optical tweezers instruments use the forces of laser radiation pressure to trap small particles. Using various techniques, these trapped particles can then be manipulated and forces on the objects in the trap can be measured. The forces that such an instrument is capable of measuring are of the order of one to 100 piconewtons (pN). While this technique has been used for over 20 years to manipulate and study the properties of micron-sized dielectric particles, it is only recently that this precise force measurement instrument has been applied to the study of biological systems.

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Touching the microworld with force-feedback optical tweezers.

Optical tweezers are a powerful tool for micromanipulation and measurement of picoNewton sized forces. However, conventional interfaces present difficulties as the user cannot feel the forces involved. We present an interface to optical tweezers, based around a low-cost commercial force feedback device. The different dynamics of the micro-world make intuitive force feedback a challenge. We prop...

متن کامل

Invited article: a review of haptic optical tweezers for an interactive microworld exploration.

This paper is the first review of haptic optical tweezers, a new technique which associates force feedback teleoperation with optical tweezers. This technique allows users to explore the microworld by sensing and exerting picoNewton-scale forces with trapped microspheres. Haptic optical tweezers also allow improved dexterity of micromanipulation and micro-assembly. One of the challenges of this...

متن کامل

Probing Thermodynamics of Small Systems over Small Timescales Using Optical Tweezers

In the past decade, Atomic Force Microscopy (AFM) and Optical Tweezers (OT) have revolutionised molecular science by measuring picoNewton forces over lengthscales from 1 to 104 Å. In our laboratory, we have an Optical Tweezer Apparatus which has been extensively modified for our force measurement experiments in polymer and colloids science. The apparatus consists of an optical trap that weakly ...

متن کامل

Hemodynamic forces can be accurately measured in vivo with optical tweezers

Force sensing and generation at the tissue and cellular scale is central to many biological events. There is a growing interest in modern cell biology for methods enabling force measurements in vivo. Optical trapping allows noninvasive probing of piconewton forces and thus emerged as a promising mean for assessing biomechanics in vivo. Nevertheless, the main obstacles lie in the accurate determ...

متن کامل

Design and Construction of a New Holographic Optical Tweezers Apparatus

In the last decade, Atomic Force Microscopy (AFM) and Optical Tweezers (OT) have revolutionised molecular science by measuring picoNewton forces over lengthscales from 1 to 104 Å. Our research focuses upon experiments using the technique of OT, but we are also involved in theory and simulation that is complementary to these OT measurements. The OT apparatus is based upon a focused laser beam th...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2002