Reply to Eisenhut

Reply to Eisenhut.

TO THE EDITOR—We appreciate the comments of Eisenhut [1] regarding the possibility that the correlation of elevated erythropoietin (EPO) levels with mortality in our recent study may in fact reflect a role for increased hemolysis in cerebral malaria [2]. Dr Eisenhut's comments led us to conduct additional analysis of markers of hemolysis in our study participants.

Reply to Eisenhut.

TO THE EDITOR—We thank Dr Eisenhut for his comments regarding possible myocarditis associated with human parechovirus-3 (HPeV-3) infection [1]. With respect to the cohort of 118 children we reported on from New South Wales, Australia [2], and further review of the medical records, 10 children had transthoracic echocardiograms that did not demonstrate evidence of myocarditis. All evaluations wer...

Reply to Eisenhut.

TO THE EDITOR—We thank Eisenhut for his interest in our article. A systemic inflammatory response appears to be a common response in both malaria and bacterial infections, with increased body temperature seen in both conditions. However, while studies in children are lacking, we and other investigators have noted a difference in oxygen consumption in adults with malaria, compared to those with ...

A Problem in Avicennas View on the Origination of the Soul and a Reply to It

Reply to Eisenhut

1 TO THE EDITOR—In response to our recent article on sex differences in pediatric infectious diseases [1], Eisenhut [2] highlighted the role of nucleotide binding oligomerization domain receptor 2 (NOD2) in the nonspecific (heterologous) effects of BCG immunization in reducing tuberculosis-unrelated diseases that are observed especially in females. We make 2 further points here. First, the nons...