A Protein Structural Alphabet and Its Substitution Matrix CLESUM
نویسندگان
چکیده
By using a mixture model for the density distribution of the three pseudobond angles formed by Cα atoms of four consecutive residues, the local structural states are discretized as 17 conformational letters of a protein structural alphabet. This coarse-graining procedure converts a 3D structure to a 1D code sequence. A substitution matrix between these letters is constructed based on the structural alignments of the FSSP database.
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عنوان ژورنال:
- Trans. Computational Systems Biology
دوره 2 شماره
صفحات -
تاریخ انتشار 2005