Antiretroviral Activity Of a Novel Pyrimidyl-Di(Diazaspiroalkane) Derivative
نویسندگان
چکیده
A novel compound, 3,3'-(5-nitropyrimidine-4,6-diyl)bis-3,12-diaza-6,9-diazoniadispiro[5.2.5.2]hexadecane tetrachloride dihydrochloride, was synthesized. The compound was found to inhibit the replication of various viral families by blocking specific heparan sulfate receptors on the host cell's surface. In experiments, the compound was found to be highly effective against several strains of HIV retroviruses.
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عنوان ژورنال:
دوره 9 شماره
صفحات -
تاریخ انتشار 2017