0329. Beneficial effects of azithromycin combined with ceftazidime without activity against P. aeruginosa in a murine sepsis model of peritonitis by Pseudomonas aeruginosa

Introduction Despite a proper management, the mortality of patients with severe sepsis and septic shock is very high. During sepsis, an uncontrolled cascade of inflammatory mediators is triggered, leading to tissue damage that can cause death. Macrolides, apart from their antibiotic properties, are capable of modulating inflammatory response. Macrolides inhibit the production and secretion of pro-inflammatory cytokines (IL-1, IL-6, IL-8 and TNF-a) levels and increase anti-inflammatory cytokines such as IL-10.