B Cell Liaison Confounds HIV-1 Evolution
نویسنده
چکیده
B cells expressing potent and broadly neutralizing antibodies to HIV-1 have been found in many infected individuals, suggesting that adaptive immunity has the capacity to defeat viral escape. Gao et al. uncover an intermediate stage in this process when viral escape from one "helper" B cell lineage selects variants that drive a separate B cell lineage toward broad neutralization.
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عنوان ژورنال:
- Cell
دوره 158 شماره
صفحات -
تاریخ انتشار 2014