Silent Mutations Make Some Noise

نویسندگان

  • Siyuan Zheng
  • Hoon Kim
  • Roel G.W. Verhaak
چکیده

Synonymous mutations do not alter amino acids and are generally considered nonfunctional in cancer. Supek et al. now present a compelling analysis suggesting that such silent mutations can be oncogenic by altering transcript splicing and thereby affecting protein function.

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عنوان ژورنال:
  • Cell

دوره 156  شماره 

صفحات  -

تاریخ انتشار 2014