Simulated Cell Division Processes of the Xenopus Cell Cycle Pathway by Genomic Object Net
نویسندگان
چکیده
Matsuno et al.[1] modeled and simulated that multicellular patterning by the Drosophila Delta-Notch signaling pathway by using the software "Genomic Object Net" which was developed based on hybrid functional Petri net (HFPN) architecture. In this model, cellular formation is fixed throughout the simulation. This paper constructs an HFPN model of the Xenopus cell cycle pathway, which includes the mechanism for cell division control as well as checkpoint processes. This model simulates dynamic cell division processes of the early Xenopus embryo, including the changes in cell division cycles from synchronous to asynchronous.
منابع مشابه
Xenopus Cell Cycle Pathway for Simulating Cell Division Processes by Genomic Object Net
To establish methods for modeling multicellular systems is the current important issues in biopathway simulations. This paper proposed a new method for modeling cell division processes with using a famous multicellular phenomenon “the changes in cell division cycles from synchronous to asynchronous in Xenopus” and succeeded in simulating this phenomenon with GON. Matsuno et al. [3] modeled and ...
متن کاملModeling and Simulation of Fission Yeast Cell Cycle on Hybrid Functional Petri Net
Through many researches on modeling and analyzing biological pathways, Petri net has recognized as a promising method for representing biological pathways. Recently, Matsuno et. al. (2003) introduced hybrid functional Petri net (HFPN) for giving more intuitive and natural biological pathway modeling method than existing Petri nets. They also developed Genomic Object Net (GON) which employs the ...
متن کاملO-10: A Marked Animal-Vegetal Polarity in The Localization of Na+,K+-ATPase Activity and Its Down-Regulation Following Progesterone-Induced Maturation
Background: Polarized cells are key to the process of differentiation. Xenopus oocyte is a polarized cell that has complete blue-print to differentiate 3 germ layers following fertilization, as key determinant molecules (Proteins and RNAs) are asymmetrically localized. The objective of this work was to localize Na+, K+-ATPase activity along animal-vegetal axis of polarized Xenopus oocyte and fo...
متن کاملFicus auriculata (fig) Extracts Induced Cell Cycle Profile Changes and Apoptosis Through Caspase-Independent Pathway in Human Lung Adenocarcinoma Cell Line, A549
Background: Ficus auriculata (fig) has immense value of benefits with regards to their medicinal and therapeutic properties. It has been long used in traditional folk medicine, and one of the fruits mentioned in Al-Quran. Many scientific researches have proven the usage of this natural medicine in in vitro and in vivo studies, where anti-cancer is among of its recognized properties. Objective...
متن کاملNitric oxide coordinates cell proliferation and cell movements during early development of Xenopus.
The establishment of a vertebrate body plan during embryogenesis is achieved through precise coordination of cell proliferation and morphogenetic cell movements. Here we show that nitric oxide (NO) suppresses cell division and facilitates cell movements during early development of Xenopus, such that inhibition of NO synthase (NOS) increases proliferation in the neuroectoderm and suppresses conv...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- J. Integrative Bioinformatics
دوره 1 شماره
صفحات -
تاریخ انتشار 2004