Correction: Differential Inhibition of the TGF-β Signaling Pathway in HCC Cells Using the Small Molecule Inhibitor LY2157299 and the D10 Monoclonal Antibody against TGF-β Receptor Type II

نویسندگان

  • Francesco Dituri
  • Antonio Mazzocca
  • Fernando Juan Peidrò
  • Patrizia Papappicco
  • Isabel Fabregat
  • Flavia De Santis
  • Angelo Paradiso
  • Carlo Sabbà
  • Gianluigi Giannelli
چکیده

We investigated blocking the TGF-β signaling pathway in HCC using two small molecule inhibitors (LY2157299, LY2109761) and a neutralizing humanized antibody (D10) against TGF-βRII. LY2157299 and LY2109761 inhibited HCC cell migration on Laminin-5, Fibronectin, Vitronectin, Fibrinogen and Collagen-I and de novo phosphorylation of pSMAD2. LY2157299 inhibited HCC migration and cell growth independently of the expression levels of TGF-βRII. In contrast to LY2157299, D10 showed a reduction in pSMAD2 only after a short exposure. This study supports the use of LY2157299 in clinical trials, and presents new insights into TGF-β receptor cycling in cancer cells.

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عنوان ژورنال:

دوره 8  شماره 

صفحات  -

تاریخ انتشار 2013