Reversible Inhibition Monoamine Oxidase - A Improves Vascular Dysfunction in Canine Carotid Arteries Exposed to Angiotensin II
نویسندگان
چکیده
ADRIAN STURZA1,2#, LAVINIA NOVEANU1,2#, OANA DUICU1,2 MARIA DANILA1,2, NORBERT JOST1,2, DANINA MUNTEAN1,2*, MIRCEA MUNTEANU3 1“Victor Babes University of Medicine and Pharmacy, Faculty of Medicine, Department of Pathophysiology, 2 Eftimie Murgu Sq., 300041, Timisoara, Romania 2 “Victor Babes University of Medicine and Pharmacy, Center for Translational Research and Systems Medicine, 2 Eftimie Murgu Sq., 300041, Timisoara, Romania 3 “Victor Babes University of Medicine and Pharmacy, Faculty of Medicine, Department of of Internal Medicine II – Diabetes, Nutrition and Metabolic Disorders, 2 Eftimie Murgu Sq., 300041, Timisoara, Romania
منابع مشابه
Elevated pressure causes endothelial dysfunction in mouse carotid arteries by increasing local angiotensin signaling.
Experiments were performed to determine whether or not acute exposure to elevated pressure would disrupt endothelium-dependent dilatation by increasing local angiotensin II (ANG II) signaling. Vasomotor responses of mouse-isolated carotid arteries were analyzed in a pressure myograph at a control transmural pressure (PTM) of 80 mmHg. Acetylcholine-induced dilatation was reduced by endothelial d...
متن کاملMonoamine oxidase inhibition improves vascular function in mammary arteries from nondiabetic and diabetic patients with coronary heart disease.
Monoamine oxidases (MAOs) are mitochondrial enzymes with 2 isoforms that have emerged as important contributors to cardiovascular oxidative stress via the constant generation of hydrogen peroxide. The present study was purported to assess whether MAO-derived H2O2 contributes to the endothelial dysfunction in mammary arteries harvested from coronary heart disease patients with and without diabet...
متن کاملEffects of Angiotensin II Infusion on the Expression and Function of NAD(P)H Oxidase
Angiotensin II infusion causes endothelial dysfunction by increasing NAD(P)H oxidase–mediated vascular superoxide production. However, it remains to be elucidated how in vivo angiotensin II treatment may alter the expression of the gp91 isoforms and the endothelial nitric oxide synthase (NOS III) and subsequent signaling events and whether, in addition to the NAD(P)H oxidase, NOS III contribute...
متن کاملEffects of angiotensin II infusion on the expression and function of NAD(P)H oxidase and components of nitric oxide/cGMP signaling.
Angiotensin II infusion causes endothelial dysfunction by increasing NAD(P)H oxidase-mediated vascular superoxide production. However, it remains to be elucidated how in vivo angiotensin II treatment may alter the expression of the gp91(phox) isoforms and the endothelial nitric oxide synthase (NOS III) and subsequent signaling events and whether, in addition to the NAD(P)H oxidase, NOS III cont...
متن کاملInhibition of neointima by angiotensin-converting enzyme inhibitor in porcine coronary artery balloon-injury model.
Because hepatocyte growth factor (HGF) stimulates growth of endothelial cells exclusively without replication of vascular smooth muscle cells, we hypothesized that HGF may play a role in cardiovascular disease. In human vascular smooth muscle cells, angiotensin II suppressed local vascular HGF production in a dose-dependent manner. Using a rat balloon-injury carotid artery model, we demonstrate...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2015