Hyperoxia activates ATR-Chk1 pathway and phosphorylates p53 at multiple sites
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منابع مشابه
Hyperoxia activates the ATR-Chk1 pathway and phosphorylates p53 at multiple sites.
Hyperoxia has been shown to cause DNA damage resulting in growth arrest of cells in p53-dependent, as well as p53-independent, pathways. Although H2O2 and other peroxides have been shown to induce ataxia telangiectasia-mutated (ATM)-dependent p53 phosphorylation in response to DNA damage, the signal transduction mechanisms in response to hyperoxia are currently unknown. Here we demonstrate that...
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تاریخ انتشار 2003