Management of sepsis -- Mackenzie and Lever 335 (7626): 929 -- BMJ

A favourable outcome depends on early, aggressive, treatment Antimicrobial treatment must take into account both patient susceptibilities and local resistance patterns; advice from infectious disease or microbiology colleagues is often helpful Volume resuscitation and cardiovascular support should be titrated to simple clinical end points Subtle signs of organ hypoperfusion should be sought in physically robust patients The role of activated protein C and low dose steroids remains to be clarified