A Genetic Map of the Td Locus of Neurospora Crassa.
نویسندگان
چکیده
URING the past decade, a large number of td mutants have been isolated. These mutants represent alterations of the td locus, which controls the formation of tryptophan synthetase (TSase) in Neurospora crassa. Extensive biochemical and immunological studies have shown that these allelic mutants differ from each other in their ability to form protein (CRM, “crossreacting material”) serologically related to tryptophan synthetase, and in the catalytic abilities and cofactor requirements of the CRM formed (cf. BONNER, SUYAMA, and DEMOSS 1960). The many biochemical differences detected among allelic td mutants make it possible to study the relationship between the location of mutational sites and the biological effects exerted by mutations at these sites. The present paper is concerned with a genetic fine structural analysis of the td locus. Detailed genetic maps of the locus are presented (Figures 1 and 2).
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عنوان ژورنال:
- Genetics
دوره 49 شماره
صفحات -
تاریخ انتشار 1964