Eric Allen , Wanda Snead and Alan D . Cherrington Catherine
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چکیده
[PDF] [Full Text] [Abstract] , February 1, 2008; 294 (2): E300-E306. Am J Physiol Endocrinol Metab Cherrington Z. An, C. A. DiCostanzo, M. C. Moore, D. S. Edgerton, D. P. Dardevet, D. W. Neal and A. D. Effects of the nitric oxide donor SIN-1 on net hepatic glucose uptake in the conscious dog [PDF] [Full Text] [Abstract] , April 1, 2008; 294 (4): R1197-R1204. Am J Physiol Regulatory Integrative Comp Physiol M. Nishizawa, M. Shiota, M. C. Moore, S. M. Gustavson, D. W. Neal and A. D. Cherrington Intraportal administration of neuropeptide Y and hepatic glucose metabolism
منابع مشابه
Role of the hepatic sympathetic nerves in the regulation of net hepatic glucose uptake and the mediation of the portal glucose signal.
Portal glucose delivery enhances net hepatic glucose uptake (NHGU) relative to peripheral glucose delivery. We hypothesize that the sympathetic nervous system normally restrains NHGU, and portal glucose delivery relieves the inhibition. Two groups of 42-h-fasted conscious dogs were studied using arteriovenous difference techniques. Denervated dogs (DEN; n=10) underwent selective sympathetic den...
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In individuals with type 1 diabetes, hypoglycemia is a common consequence of overinsulinization. Under conditions of insulin-induced hypoglycemia, glucagon is the most important stimulus for hepatic glucose production. In contrast, during euglycemia, insulin potently inhibits glucagon's effect on the liver. The first aim of the present study was to determine whether low blood sugar augments glu...
متن کاملInsulin secretion-independent effects of GLP-1 on canine liver glucose metabolism do not involve portal vein GLP-1 receptors.
Whether glucagon-like peptide (GLP)-1 requires the hepatic portal vein to elicit its insulin secretion-independent effects on glucose disposal in vivo was assessed in conscious dogs using tracer and arteriovenous difference techniques. In study 1, six conscious overnight-fasted dogs underwent oral glucose tolerance testing (OGTT) to determine target GLP-1 concentrations during clamp studies. Pe...
متن کاملEffect of 11 -hydroxysteroid dehydrogenase-1 inhibition on hepatic glucose metabolism in the conscious dog
Dale S. Edgerton, Rita Basu, Christopher J. Ramnanan, Tiffany D. Farmer, Doss Neal, Melanie Scott, Peer Jacobson, Robert A. Rizza, and Alan D. Cherrington Department of Molecular Physiology and Biophysics, Vanderbilt University Medical Center, Nashville, Tennessee; Department of Endocrinology, Metabolism, and Nutrition, Mayo Clinic College of Medicine, Rochester, Minnesota; and Abbott Laborator...
متن کاملEffect of intraportal glucagon-like peptide-1 on glucose metabolism in conscious dogs.
Arteriovenous difference and tracer ([3-(3)H]glucose) techniques were used in 42-h-fasted conscious dogs to identify any insulin-like effects of intraportally administered glucagon-like peptide 1-(7-36)amide (GLP-1). Each study consisted of an equilibration, a basal, and three 90-min test periods (P1, P2, and P3) during which somatostatin, intraportal insulin (3-fold basal) and glucagon (basal)...
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تاریخ انتشار 2005