Adiponectin decreases postprandially following a heat-processed meal in individuals with type 2 diabetes: an effect prevented by benfotiamine and cooking method.
نویسندگان
چکیده
Adiponectin regulates insulin sensitivity (1), reduces the expression of endothelial adhesion molecules (2), and has anti-inflammatory effects (3). Decreased adiponectin levels accompany obesity (4) and type 2 diabetes (5), promoting insulin resistance (5) and cardiovascular disease (6,7). Data on postprandial adiponectin regulation in different populations are controversial, with studies showing no effect (8 –11), increases (12,13), or decreases (14,15). Advanced glycation end products (AGEs) (16) play a major role in the development of diabetes complications (17). We have shown that dietary AGEs acutely impair endothelial function (18,19), an effect counteracted by benfotiamine (20), a transketolase activator that blocks several hyperglycemiainduced pathways, including the formation of AGEs (21). AGEs might interact with adipocytes through AGE receptors (22) and induce cellular dysfunction via generation of reactive oxygen species (23), a pathway probably responsible for the AGE-induced downregulation of leptin secretion in vitro (24). Our study aimed at investigating the effects of a high heat–processed meal with high AGE content (HAGE) and a low heat–processed meal with low AGE content (LAGE) on postprandial adiponectin concentration. We postulated a protective effect of benfotiamine.
منابع مشابه
Adiponectin Decreases Postprandially Following a Heat Processed Meal in People with Type 2 - an Effect Prevented by Benfotiamine and Cooking Method
متن کامل
Benfotiamine prevents macro- and microvascular endothelial dysfunction and oxidative stress following a meal rich in advanced glycation end products in individuals with type 2 diabetes.
OBJECTIVE Diabetes is characterized by marked postprandial endothelial dysfunction induced by hyperglycemia, hypertriglyceridemia, advanced glycation end products (AGEs), and dicarbonyls (e.g., methylglyoxal [MG]). In vitro hyperglycemia-induced MG formation and endothelial dysfunction could be blocked by benfotiamine, but in vivo effects of benfotiamine on postprandial endothelial dysfunction ...
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عنوان ژورنال:
- Diabetes care
دوره 30 10 شماره
صفحات -
تاریخ انتشار 2007