Plasma Level of Protein C, Fibrinogen Concentration, and Platelet Number in Dogs with Legg-calve-perthes Disease and Osteochondrosis. Preliminary Studies

The possible role of coagulatory disorders in pathogenesis of Legg-Calve-Perthes disease (LCPD) and osteochondrosis (OC) was examined. A decrease in protein C level in dogs with LCPD (94.31±4.74%) in comparison with healthy dogs (95.8±6.35%) was observed. Moreover, in OC affected animals, the value varied between 92.25±2.5% and 94.33±5.5%. The mean plasma fibrinogen level in control group was 2.69±0.65 mg/mL, whereas in OC groups significantly higher values were found. Platelets number varied between individuals but was within normal range in all groups. Taking into account a decrease in protein C plasma level and an increase in fibrinogen concentration, the relationship between developmental diseases and coagulation disorders was revealed in dogs.