Fibrinolysis: Why Clot Breakdown May be Just as Important as Making the Clot
نویسنده
چکیده
Diagnosis and treatment of coagulation disorders associated with many veterinary diseases have been well studied, but the degree to which disorders of fibrinolysis may contribute to bleeding in veterinary patients is unknown. Recent data in the human and experimental literature suggests that the fibrinolytic pathway may be a useful target in patients with bleeding disorders and thrombotic disease.
منابع مشابه
بررسی تاثیر عناصر مس، روی و آلومینیوم بر شاخصهای انعقاد و فیبرینولیز
Introduction: Myocardial infarction as a leading cause of death in most populations is associated with blood clot formation in coronary artery, and rapid clot lysis is important for patient treatment. Some reports have indicated the effects of some trace elements on blood coagulation and clot lysis. The aim of this study was to evaluate the effects of zinc, copper and aluminum on in-vitro coagu...
متن کاملThrombin activatable fibrinolysis inhibitor (TAFI) at the interface between coagulation and fibrinolysis.
The thrombin-catalysed conversion of plasma fibrinogen into fibrin and the development of an insoluble fibrin clot are the final steps of the coagulation cascade during haemostasis. A delicate balance between coagulation and fibrinolysis determines the stability of the fibrin clot. Thrombin Activatable Fibrinolysis Inhibitor (TAFI) plays an important role in this process. TAFI is activated by t...
متن کاملBlood Clot Structure and Fibrinolysis in Cardiovascular Conditions
Blood clot structure plays a role in predisposition to atherothrombotic disease, as compact clots are associated with premature and more severe cardiovascular disease. Some genetic variants of clotting factors have been associated with an increased risk of thrombosis by mechanisms that may involve alteration in clot structure. In addition to genes, environmental factors, such as obesity, diabet...
متن کاملStreptokinase for Treatment of Thrombotic Disorders: The End? Or the End of the Beginning?
Thrombotic disorders, such as myocardial infarction, ischemic stroke, peripheral arterial disease, deep venous thrombosis, pulmonary embolism, or other embolic diseases that are responsible for worldwide mortality and morbidity, are manifestations of the formed thrombi by blood clots during a pathologic blood coagulation process. Once thrombi are formed, the only way to resolve the blood clot i...
متن کاملThromboaspiration in the basilar artery: report of two cases.
Recanalization of the basilar artery is not always achieved with intraarterial fibrinolysis. We report two cases of thromboaspiration in the basilar artery in which recanalization with fibrinolysis was successful. Thromboaspiration requires favorable anatomy and a fresh nonadhesive clot. It reduces the time for recanalization, has no hemorrhagic risk, and may prevent distal clot migration. Thro...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2015