A case of 5-fluorouracil induced encephalopathy.

نویسندگان

  • Kyung A Kwon
  • Hyuk-Chan Kwon
  • Min Chan Kim
  • Sung-Hyun Kim
  • Sung Yong Oh
  • Suee Lee
  • Hyo-Jin Kim
چکیده

Patients with reduced dihydropyrimidine dehydrogenase (DPD) activity are at risk for experiencing serious adverse effects following 5-fluorouracil (5-FU) based chemotherapy. Neurotoxicity is considered an extremely rare side effect of 5-FU. We report here on an unusual case of 5-FU induced encephalopathy. A 38-year-old woman with advanced gastric carcinoma was treated with adjuvant chemotherapy that consisted of infused 5-FU (1,000 mg/m²) for 5 days and cisplatin (60 mg/m²) on day 1 following total gastrectomy. Nineteen days after starting chemotherapy, the patient displayed a sudden onset of slurred speech, confusion, cognitive disturbances and paranoia. A magnetic resonance image (MRI) of the brain showed no structural abnormalities, and the other laboratory tests provided no explanations for her symptoms, other than a slightly elevated ammonia level. The patient was treated with a lactulose retention enema and thiamine infusion, the 5-FU was halted and her symptoms then recovered after 7 days.

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عنوان ژورنال:
  • Cancer research and treatment : official journal of Korean Cancer Association

دوره 42 2  شماره 

صفحات  -

تاریخ انتشار 2010