Requirement for PARP-1 in the recruitment of aprataxin to sites of DNA breaks
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چکیده
Poly-ADP ribose polymerase 1 (PARP-1) is a protein well described as a sensor for single strand DNA breaks (SSB) [1]. After its activation a localized poly(ADPribosyl)ation of proteins near the DNA breaks is initiated, which is necessary for efficient binding of other repair proteins like XRCC1. The aprataxin protein has interaction domains for both SSB-repair proteins such as PARP1 and XRCC1 and double strand (DSB)-repair proteins like XRCC4 [2, 3]. This suggests a requirement for aprataxin in multiple repair pathways. Here the functional interaction of aprataxin and PARP-1 after heavy ion irradiation is analyzed using different imaging techniques [4].
منابع مشابه
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تاریخ انتشار 2010