A Software Framework for Integrative Physiological Model Simulation

Emergence of systems biology motivated more comprehensive and integrative approaches for modeling physiological processes. Presented study proposes a software framework to integrate multilevel and multiscale models for physiological processes. The aim of the study is to provide the interfacing mechanisms to facilitate the integration of models from multiple research groups increasing the ability to construct complex simulations of physiological models. In this paper, high level design of the proposed system, integration of physiological models and the architecture to modularize the integration are presented. As the proposed system targets a multiscale and multilevel integration of mathematical models, complex diseases or physiological processes effecting many organs or organ systems, like diabetes, are within in the application areas. Besides enhancing the model development processes; the presented study will accelerate the development, analysis and testing of integration approaches for multiscale and multilevel physio-