Speed Response to a Vectored Retroviral Antigen Is T Cell + Clonotypic Composition
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چکیده
منابع مشابه
Clonotypic composition of the CD4+ T cell response to a vectored retroviral antigen is determined by its speed.
The mechanisms whereby different vaccines may expand distinct Ag-specific T cell clonotypes or induce disparate degrees of protection are incompletely understood. We found that several delivery modes of a model retroviral Ag, including natural infection, preferentially expanded initially rare high-avidity CD4(+) T cell clonotypes, known to mediate protection. In contrast, the same Ag vectored b...
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تاریخ انتشار 2014