Dental Pulp Stem Cell Cleft Genes Differential Expression and Developmental Influence during Palatogenesis
نویسنده
چکیده
Background: Although cleft lip and palate deformities are the most common facial birth defect (1 in 600 births), only a few genes, IRF6 (associated with Van der Wounde) and transforming growth factor-beta 3 (TGFB3), have been implicated in the disease. Dental pulp stem cells (DPSC) have similar developmental process with neural crest migration into core mesoderm and ectoderm and may be used to gain insight into the cell matrix interaction of epithelial-mesenchymal transition (EMT) during palatogenesis. Previous microarray comparative analysis of cleft dental pulp stem cells identi ed candidate genes (MMP3, ACAN, COL4A1, COL4A2, and COL15A1) known to be involved in cell matrix interaction of the EMT during palatogenesis.
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تاریخ انتشار 2013