All Solid Sate Potentiometric Sensors for Granisetron Hydrochloride in Pharmaceutical Formulation

Granisetron content of some pharmaceutical tablets was determined using a novel all-solid-state polymeric-membrane-electrode (ASS-PME) having a sensing element functioning based on an ion-exchange mechanism. The best results were observed with ASSPMEs containing 8% GST-tetrakis (p-chlorophenyl) borate as the ion-pair, 56% of dibutyl phthalate, 31% of poly(vinyl chloride), 3% of an ionic liquid and 2% of KpClTPB. The ASS element of the device was a conductive composite of graphite, MWCNTs, and an epoxy resin coated on a copper wire, and the PVC membranes were coated on the ASS. The ASS-PME showed a Nernstian response of 58.1±0.2 mV/decade over the range of 1.0×10-6 to 1.0×10-3 M. The application of the device was validated and the method was found to be applicable in the analysis of Granisetron hydrochloride in pharmaceutical formulations. KeywordsSensor, Granisetron, Polymeric membrane, All solid state, Potentiometry, Pharmaceutical formulation Analytical & Bioanalytical Electrochemistry 2017 by CEE www.abechem.com Anal. Bioanal. Electrochem., Vol. 9, No. 2, 2017, 232-244 233