Lessons in Hope
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چکیده
Today, anyone who follows HIV treatment with a casual interest may get the impression that things are progressing wonderfully. A recent publication of the Pharmaceutical Manufacturers’ Association asserts that 82 new medicines are in development for treating various aspects of HIV infection. Of these, 36 are antivirals, the kind of drugs that has made the most profound advances against HIV and AIDS. Surely, this sounds like good news, especially for those who have developed resistance to the current therapies. We’ve been hearing for years of the likely wonders of a new class of drugs called entry inhibitors as well as hoping for better drugs in the existing classes. For people with HIV, this was expected to be a cheerful holiday season indeed. It wasn’t. Instead, the last half of 2005 offered one of the most discouraging lessons in drug development in a long time. News came of the complete failure of one entry inhibitor candidate and the partial failure of two another, as well as discouraging results in some of the studies of new NRTIs. Though one new protease inhibitor came to market promising to help people with highly resistant virus, it offered limited utility, significant toxicity and exorbitant cost. Shortly after 2006 began, the largest-ever study that tested whether people needed to be on constant therapy was abruptly halted. All in all, this was one heck of a discouraging period. In the interests of keeping hope alive, it’s important to remember that the media’s coverage of HIV issues tends to exaggerate the truth, whether good or bad. That is once again the case. Though some setbacks have occurred, several striking successes have gotten little or no fanfare. It’s appropriate then that we start the New Year by looking not only at the failures, but also at some of what’s working ... and working well.
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تاریخ انتشار 2006