Haemolytic Disease of the Fetus and Newborn

Necrotizing enterocolitis in a newborn following intravenous immunoglobulin treatment for haemolytic disease.

ABO iso-immunization is the most frequent haemolytic disease of the newborn. Treatment depends on the total serum bilirubin level, which may increase very rapidly in the first 48 hours of life in cases of haemolytic disease of the newborn. Phototherapy and, in severe cases, exchange transfusion are used to prevent hyperbilirubinaemic encephalopathy. Intravenous immunoglobulins (IVIG) are used t...

BCSH guideline for the use of anti-D immunoglobulin for the prevention of haemolytic disease of the fetus and newborn.

Practical effects of blood group incompatibility between mother and fetus.

It was Ford' who first suggested that advantages and disadvantages, such as susceptibility to certain diseases, would be found to be associated with the human blood groups. Nevertheless, it was many years before practical work was started on the subject and only when Aird et al.2 had shown that a significantly high proportion of patients with cancer of the stomach belong to group A and of those...

Direct antiglobulin reaction in ABO-haemolytic disease of the newborn.

The minimum number of IgG anti-A (or anti-B) molecules detectable on A or B red cells by the antiglobulin reaction was found to be the same-that is, about 150 molecules per red cell-with newborn as with adult cells. Furthermore, the ratio of anti-IgG bound to IgG anti-A (or anti-B) molecules was the same whether the anti-A (or anti-B) molecules were present on newborn or on adult cells and was ...

Severe hydrops in the infant of a Rhesus D-positive mother due to anti-c antibodies diagnosed antenatally: a case report

INTRODUCTION Rhesus haemolytic disease of the newborn is a prototype of maternal isoimmunisation and fetal haemolytic disease. There are other rare blood group antigens capable of causing alloimmunisation and haemolytic disease such as c, C, E, Kell and Duffy. In India, after the confirmation of a newborn's blood group, antibodies are screened only if the mother is Rehsus D-negative negative an...

Transfusion Medicine | GUIDELINES BCSH guideline for the use of anti-D immunoglobulin for the prevention of haemolytic disease of the fetus and newborn

H. Qureshi,1 E. Massey,2 D. Kirwan,3 T. Davies,4 S. Robson,5 J. White,6 J. Jones7 & S. Allard8 1Department of Haematology, University Hospitals of Leicester, Leicester, UK, 2NHS Blood & Transplant, Bristol, UK, 3NHS Fetal Anomaly Screening Programme, UK National Screening Committee, University of Exeter, Exeter, UK, 4NHS Blood & Transplant, Manchester, UK, 5Department of Fetal Medicine, Institu...